G. Marius Clore received the 2011 Centenary Prize from the Royal Society of Chemistry for his work pioneering computational chemistry coupled with multidimensional nuclear magnetic resonance (NMR) data. His work has greatly expanded our ability to characterize biological macromolecules using NMR. Clore is a distinguished research fellow at the US National Institutes of Health and holds dual British and US citizenship. His laboratory studies the dynamics and structure of proteins, protein–protein complexes, and protein–nucleic acid complexes. Clore’s work has led to an expanded understanding of genetic signal transduction and transcriptional regulation as well as AIDS and AIDS-related proteins.